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NFL Week 6 Inactives: Key Players Missing, Impacts Unfold

October 12, 2025
  • #NFL
  • #FantasyFootball
  • #Inactives
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  • #KylerMurray
  • #AlvinKamara
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NFL Week 6 Inactives: Key Players Missing, Impacts Unfold

Week 6 NFL Inactives: Who's In and Who's Out?

As a lead sports reporter with a passion for decoding the game, I know how vital it is for fantasy football enthusiasts to stay informed about player statuses before the matchups commence. With Week 6 upon us, we see significant inactives, including Arizona's star quarterback Kyler Murray and Los Angeles Chargers' wide receiver Quentin Johnston. These changes could alter the strategic landscape for fantasy football players everywhere.

Significant Player Inactives

Let's break down who's officially out this week and the immediate implications:

  • Kyler Murray, QB, ARI (foot) - After a week of limited practice, Murray has been confirmed inactive. This paves the way for Jacoby Brissett to step in, which significantly alters the Cardinals' offensive approach. Fantasy owners should reassess whether to start any of their receiving options this week.
  • Quentin Johnston, WR, LAC (hamstring) - Johnston's absence opens the door for other wide receivers like Keenan Allen and rookie Ladd McConkey to step into increased roles. If you're banking on production from the Chargers, these are names to consider.

Players Who Will Play

In contrast, not all news is dire:

  • Alvin Kamara, RB, NO (ankle) - Kamara is declared active after limited participation during the week. With his return, expect a split in carries with Kendre Miller, which could complicate start decisions in leagues that lean heavily on running back production.

Impact on Fantasy Strategies

These updates are crucial for any serious fantasy football competitor. Knowing who's out can instantly elevate player values—Jacoby Brissett, although not a direct replacement for Murray, could have a surprisingly competitive outing, especially with a favorable matchup.

For Johnston's absence, many owners may need to pivot and find a reliable option on the waiver wire. Think about players who could see increased volume—this could be a key week to grab someone who can put up solid points while substitutes are required.

Injuries and Long-Term Implications

As the injuries pile up, I can't stress enough how critical it is to keep an eye on these situations for the weeks ahead. Player performances can have a ripple effect on their team's dynamics, potentially altering strategies for the entire season—not just for fantasy football but for how fans perceive each respective squad.

Check-In Before Kickoff

Remember, official inactives are reported about 90 minutes before kickoff, so ensure you're refreshing your feeds regularly. Knowledge is power in the realm of fantasy sports, and I aim to keep you well-informed!

Final Thoughts

“As sports fans, especially in the fantasy realm, we need to stay ahead of the curve. Knowledge is your best strategy when setting those all-important lineups.”

For more in-depth coverage and analysis, check out ESPN Fantasy's full article, and hopefully, this week's lineups pan out in your favor!

Source reference: https://www.espn.com/fantasy/football/story/_/page/FFSundayInactives-46507865/nfl-fantasy-football-espn-injured-inactives-watchlist-week-6-2025-october-12

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